分析拉莫三嗪对难治性癫痫患儿的疗效及作用

Effect of lamotrigine in children with intractable epilepsy and its effect on EEG activity

目的观察拉莫三嗪对难治性癫痫患儿的疗效及作用。方法 85例难治性癫痫患儿采用随机数字表法分为常规组(41例)、联合组(44例)。2组均予以常规药物,联合组另予以拉莫三嗪治疗。对比癫痫发作频率、每次发作持续时间变化,疗效,脑电活动特征改变,治疗前后血清脑源性神经营养因子(BDNF)和神经生长因子(NGF)水平改变,不良反应。结果 2组治疗前癫痫发作频率、每次发作持续时间差异均无统计学意义(P>0.05),治疗后癫痫发作频率均下降,每次发作持续时间均缩短,且治疗后联合组癫痫发作频率低于常规组,且每次发作持续时间短于常规组,差异均有统计学意义(P<0.05);2组联合组总有效率是88.37%,高于常规组的64.10%,差异有统计学意义(P<0.05);治疗后联合组广泛性异常、局限性异常、背景活动异常发生率均低于治疗前和常规组治疗后,差异均有统计学意义(P<0.05);2组治疗后血清BDNF和NGF水平均升高,且联合组均高于常规组,差异均有统计学意义(P<0.05);2组不良反应发生率差异无统计学意义(P>0.05)。结论对难治性癫痫患儿予以拉莫三嗪可降低癫痫发作频率,缩短每次发作持续时间,疗效理想,还可纠正异常脑电活动,提高血清BDNF和NGF水平,且安全。

Objective:To observe the therapeutic effect and role of lamotrigine on children with intractable epilepsy.Methods:85 children with intractable epilepsy were divided into routine group(41 cases)and combined group(44 cases)by a random digital table.Both groups were given routine drugs,and lamotrigine was added to the combined group.The frequency of epileptic attack,the duration of each attack,the therapeutic effect,the change of EEG activity characteristics,changes of serum brain-derived neurotrophic factor(BDNF)and nerve growth factor(NGF)levels before and after treatment and adverse reactions were compared.Results:There was no significant difference in seizure frequencies and duration between the two groups(P>0.05),and the seizure frequencies decreased after treatment,the duration was shortened,and the seizure frequency in the combined group after treatment was lower,the duration was shorter,with statistically significant differences(P<0.05).The total effective rate of the combined group was 88.37%,higher than that of 64.10% in the routine group,with a statistically significant difference(P<0.05).After treatment,the incidence of extensive abnormality,local abnormality and background activity abnormality in the combined group were lower than those before treatment and the routine group after treatment,with statistically significant differences(P<0.05).After treatment,the serum BDNF and NGF levels in the two groups increased,which in the combined group were higher than those in the routine group,with statistically significant differences(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Lamotrigine can reduce the frequency of epileptic attack,shorten the duration of each attack,the curative effect is ideal,and it can also correct abnormal EEG activities,improve the serum BDNF and NGF levels,and it is safe.