摘要
目的:了解头孢曲松致儿童不良反应(ADR)发生情况及其发生规律。方法:检索并提取万方数据库中有关头孢曲松引起ADR的案例报告(1998-2018年),按年龄、性别、给药途经、原患疾病、发生时间、预后等进行统计分析。结果:头孢曲松引起ADR以3~6岁的儿童发生较多(35.62%);静脉滴注(97.26%)是发生ADR的主要给药途径;累及系统/器官以全身性损害(31.51%),肝胆系统损害(21.92%),血小板和出血、凝血异常(12.33%);主要临床表现为过敏性休克19例(26.03%);发生时间多为用药后10 min(23.29%)。过敏性休克多发生于用药5 min内(36.84%)。3例(4.11%)死亡。结论:临床应重视头孢曲松在青少年及儿童中引起的ADR,确保用药安全。
Objective:To investigate the situation and regularity of adverse drug reaction(ADR)in children induced by ceftriaxone.Methods:Case report of ADR induced by ceftriaxone in Wanfang database from 1998 to 2018 were retrieved and extracted.Statistical analysis was conducted on age,gender,route of administration,original disease,occurrence time and prognosis.Results:ADR induced by ceftriaxone was more common in children aged from 3 to 6 years(35.62%).Intravenous infusion(97.26%)was the main route of administration for ADR.Systems/organs involved were systemic damage(31.51%),hepatobiliary system damage(21.92%),abnormal platelets,bleeding and coagulation(12.33%).The main clinical manifestations were 19 cases(26.03%)of anaphylactic shock,the occurrence time of ADR was mostly 10 min after administration(23.29%).Anaphylactic shock mostly occurred within 5 min after administration(36.84%).There were 3 cases(4.11%)died.Conclusion:Clinical attention should be paid to ADR induced by ceftriaxone in adolescents and children to ensure medication safety.
作者
范铭
Fan Ming(Shanghai Minhang District Central Hospital,Shanghai 201199,China)
出处
《儿科药学杂志》
CAS
2021年第3期47-50,共4页
Journal of Pediatric Pharmacy
关键词
头孢曲松
儿童
不良反应
文献分析
ceftriaxone
children
adverse drug reactions
literature review