生命质量调整的无症状或不良反应时间方法及其应用介绍

Introduction of Quality Adjusted Time without Symptoms or Toxicity Method and Its Application

质量调整生存分析方法是将生命质量和生存时间两个测量指标整合为单个测量指标的综合疗效评价方法,包括质量调整生命年(QALYs)和生命质量调整的无症状或不良反应时间(Q-TWiST)等方法。QALYs常用于卫生经济学中且已被国内外学者所认可,Q-TWiST常用于治疗肿瘤药物疗效评估,在国外得到较为广泛应用,但国内应用甚少。鉴于目前国内缺乏对该方法的系统介绍,本研究将对Q-TWiST方法及其应用进行梳理,以期为国内肿瘤领域全面评估药物疗效提供相关参考与借鉴。

The quality-adjusted survival analysis method is a comprehensive efficacy evaluation method that integrates the 2 latitude measurement indicators of quality of life and survival time,including quality-adjusted life years(QALYs)and quality adjusted time without symptoms or toxicity(Q-TWiST)and other methods.QALYs are commonly used in health economy and have been recognized by scholars at home and abroad.Q-TWiST is often used to evaluate the efficacy of tumor drugs.It is widely used abroad,but it is rarely used domestically.In view of the current lack of systematic introduction of this method in China,this article systematically summarized Q-TWiST method and its application,so as to provide references for the comprehensive evaluation of drug efficacy in the domestic tumor field.