摘要
细菌外膜囊泡(outer membrane vesicles,OMVs)的免疫原性强,在体外不复制增殖,且可将其他候选抗原包载,使其表达在OMVs表面,提高抗原递呈效率的特性。本文就近些年细菌OMVs制备与修饰、诱导免疫应答以及疫苗应用的研究进展进行综述,以期为进一步了解细菌OMVs的特性及其未来应用前景提供参考。
Bacterial outer membrane vesicles(OMVs)are highly immunogenic,and do not replicate in vitro,which can entrap and express other candidate antigens on the surface of themselves to improve the efficiency of antigen presentation.This article introduced and reviewed the recent research progress in the preparation and recombination,induction of immune response and vaccine application of bacterial OMVs,in order to help the readers further understand the characteristics of bacterial OMVs and their application prospects.
作者
王珊珊
李亚南
徐颖华
叶强
WANG Shan-shan;LI Ya-nan;XU Ying-hua;YE Qiang(Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products,National Institutes for Food and Drug Control,Beijing 102629,China)
出处
《中国新药杂志》
CAS
CSCD
北大核心
2020年第24期2789-2793,共5页
Chinese Journal of New Drugs
基金
国家重点研发计划资助项目(2018YFC1603900):食品监管微生物追踪技术与网络平台的建立。
关键词
细菌外膜囊泡
免疫反应
疫苗
质量控制
bacterial outer membrane
immune response
vaccine
quality control
