新型冠状病毒重组蛋白疫苗研发进展

Research progress on novel coronavirus recombinant protein vaccines

全球通过多技术路线研发新型冠状病毒疫苗以应对新型冠状病毒肺炎疫情,其中重组蛋白疫苗项目数量最多。本文通过综述重组蛋白疫苗的工艺原理、优势和不足,以及乙型肝炎病毒、严重急性呼吸综合征冠状病毒和中东呼吸综合征冠状病毒重组蛋白疫苗研发经验,阐述目前新型冠状病毒重组蛋白疫苗研发现状,总结其预期问题和挑战。

Scientists around the world are developing candidate vaccines against the novel coronavirus,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) using a variety of technological platforms.The most common platform is based on a recombinant protein technique.In this article,we review principles,advantages,and disadvantages of recombinant protein vaccines,as well as previous research experience with recombinant protein vaccines against hepatitis B virus,severe acute respiratory syndrome coronavirus,and Middle East respiratory syndrome coronavirus.We describe the development status of SARS-CoV-2 recombinant protein vaccines and potential issues and challenges in their development.