肿瘤相关巨噬细胞在妇科恶性肿瘤中的研究进展

Research progress of tumor-associated macrophages in gynecological malignant tumors

肿瘤相关巨噬细胞(TAMs)是肿瘤微环境(TME)一种重要的炎性反应细胞,具有高度的可塑性,在肿瘤组织免疫功能的调节中发挥重要作用。TAMs在肿瘤发展的不同阶段具有不同的表型。在女性的主要恶性肿瘤中,包括卵巢癌、宫颈癌和子宫内膜癌(EC),TAMs对癌细胞的进展和远处扩散起着重要作用,因此靶向TAMs可能成为治疗妇科常见癌症的重要策略。本文对TAMs在妇科恶性肿瘤中的相关研究进展进行综述。

Tumor-associated macrophages(TAMs)is a kind of important inflammatory cell in the tumor microenvironment(TME).They have a high degree of plasticity and play an important role in the regulation of tumor tissue immune function.TAMs have different phenotypes at different stages of tumor development.Among the main malignant tumors of women,such as ovarian cancer,cervical cancer,and endometrial carcinoma(EC),TAMs plays an important role in the progression and distant spread of cancer cells.Therefore,targeting TAMs may become an important treatment strategy of common cancers in gynecology.This article reviewed the research progress of TAMs in gynecological malignant tumors.