SPOCK2基因多态性与支气管肺发育不良的关系研究进展

Relation ship study progress of SPOCK2 gene polymorphism and bronchopulmonary dysplasia

随着新生儿医学的发展及肺表面活性物质的应用,越来越多的早产儿和极低出生体重儿得以存活,但支气管肺发育不良(BPD)的发病率也在逐年增加,作为早产儿最棘手的问题之一,其发病机制尚不完全清楚,目前仍缺乏特效药物及治疗手段,因此研究BPD机制是目前新生儿科医生最具有挑战性的热门课题之一。多项研究表明,SPCOK2基因多态性与BPD的发病密切相关,该文就SPOCK2基因多态性与早产儿BPD的相关性研究进展予以综述。

With the development of neonatal medicine and the application of pulmonary surfactant,more and more premature and very low birth weight infants are surviving.However,the incidence rate of bronchopulmonary dysplasia(BPD)is increasing year by year.As the most difficult problem of premature infants,the pathogenesis is not yet fully understood,and there is still no specific drugs and treatment methods for this disease.Therefore,to study the pathogenesis of BPD is one of the most challenging and hot topics for neonatal pediatricians.A number of studies have shown that SPOCK2 gene polymorphism is closely related to the incidence of BPD.This article reviewed the research progress on the relationship between SPOCK2 gene polymorphism and BPD in preterm infants.