凝血六项与血栓弹力图评估肝癌患者凝血功能的效果分析

Analysis of the Effect of Six Items of Blood Coagulation and Thromboelastogram in Evaluating the Coagulation Function of Patients with Liver Cancer

目的:探讨凝血六项与血栓弹力图(TEG)评估肝癌患者凝血功能的效果。方法:选取2018年2月-2020年2月于新乡市第一人民医院接受手术治疗的51例肝癌患者,将其纳入观察组,并选取同期于医院接受健康体检者51例,将其纳入对照组。比较两组凝血六项、TEG水平,并分析肝癌患者围术期凝血功能。结果:观察组FIB、R、K水平低于对照组,PT、TT、APTT、FDP、D-D、α角、MA水平均高于对照组,差异有统计学意义(P<0.05);观察组FIB在T0、T1、T2呈现先降低后升高趋势;PT、TT、APTT、FDP、D-D在T0、T1、T2呈现先升高后降低趋势,差异有统计学意义(P<0.05);观察组R、K在T0、T1、T2呈现先降低后升高趋势;α角、MA在T0、T1、T2呈现先升高后降低趋势,差异有统计学意义(P<0.05)。结论:肝癌患者血液多处于高凝状态,临床可加强对肝癌患者凝血六项与TEG水平的监测,为临床实施合理的预防与治疗方案提供理论基础,有利于提升患者预后质量。

Objective:To explore the effects of six items of blood coagulation and thromboelastography(TEG)in evaluating the coagulation function of patients with liver cancer.Methods:Atotal of 51 patients with liver cancer who underwent surgical treatment in the hospital from February 2018 to February 2020 were selected and included in the observation group,and 51 patients who received a physical examination in the hospital during the same period were selected and included in the control group.The six items of blood coagulation and TEG levels were compared between the two groups,and the perioperative coagulation function of patients with liver cancer was analyzed.Results:The levels of FIB,R,and K in the observation group were lower than those in the control group,and the levels ofPT,TT,APTT,FDP,DD,α angle and MA were higher than those in the control group,the difference was statistically significant(P<0.05).In the observation group,FIB showed a trend of first decreasing and then increasing at T0,T1,T2,and PT,TT,APTT,FDP,DD showed a trend of first increasing and then decreasing at T0,T1,T2,the difference was statistically significant(P<0.05).In the observation group,R and K showed a trend of first decreasing and the nincreasing at T0,T1,andT2,α angle and MA showed atrend of first increasing and then decreasing at T0,T1,T2,and the difference was statistically significant(P<0.05).Conclusion:The blood of liver cancer patients is mostly in a hypercoagulable state,clinically,the monitoring of the six items of blood coagulation and TEG levels of patients with liver cancer can be strengthened to provide a theoretical basis for the clinical implementation of reasonable prevention and treatment programs,which will help improve the quality of patient’s prognosis.