呼出气一氧化氮在慢阻肺诊治中的运用和相关进展分析

Application of FeNO in the Diagnosis and Treatment of COPD and Analysis of Related Progress

呼出气一氧化氮(FeNO)是临床用于对气道炎症情况测量的手段,具有定量、无创以及操作简单的优势,随着医疗水平发展并对测量技术逐渐标准化,FeNO作为管理哮喘疾病的重要工具已经被广泛的应用在检测以嗜酸性粒细胞浸润所引发的气道炎症,以及评估应用糖皮质激素后的疗效情况。对慢性阻塞性肺疾病(慢阻肺)虽然已经展开关于FeNO指标检测,但单纯该指标在慢阻肺患者临床的指导价值还没有统一的认知。笔者就近年来关于FeNO在气道疾病应用相关研究进行回顾,归纳该指标参数对于慢阻肺诊疗的运用和进展。

Fractional exhaled nitric oxide(FeNO)is a clinically used method to measure airway inflammation,it has theadvantages of quantitative,non-invasive and simple operation.With the development of medical level and the gradual standardization of measurement techniques,FeNO,as an important tool for managing asthma,has been widely used to detect airway inflammation caused by eosinophil infiltration and to evaluate the efficacy of glucocorticoids.Although the FeNO index tes thas been launched for chronic obstructive pulmonary disease(COPD),there is no unified understanding of the clinical guiding value of this index in COPD patients.In recent years,the researcheson the application of FeNO in airway diseases were reviewed and the application and progress of this index parameter in thediagnosis and treatment of COPD were summarized.