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乙型肝炎病毒核衣壳组装调节剂最新进展

Advances on hepatitis B virus capsid assembly modulators
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摘要 核衣壳组装调节剂作为新型抗HBV药物,能影响HBV复制,使共价闭合环状DNA(cccDNA)暴露而便于其被降解酶降解,从而同时减少cccDNA库。本文对主要的核衣壳组装调节剂及其与HBV核心蛋白之间相互作用方面的研究进展作一综述。 The capsid assembly modulators(CAMs),as a novel anti-HBV drug,can affect HBV replication and induce the exposure of covalent closed circular DNA(cccDNA)to degrading enzymes for its degradation,thus reducing the cccDNA pool.In this paper,the development of main CAMs and their interaction with HBV core proteins are reviewed.
作者 莫佳妮 颜学兵 Mo Jiani;Yan Xuebing(Department of Infectious Diseases,the Affiliated Hospital of Xuzhou Medical University,Xuzhou 221002,Jiangsu,China)
机构地区 徐州医科大学附属医院感染性疾病科
出处 《国际流行病学传染病学杂志》 CAS 2021年第1期59-62,共4页 International Journal of Epidemiology and Infectious Disease
基金 国家科技重大专项(2018ZX10302206-003-010)。
关键词 肝炎 乙型 乙型肝炎核心蛋白 变构调节剂 核衣壳蛋白 Hepatitis B Hepatitis B core protein Allosteric modulator Nucleocapsid protein
分类号 R943 [医药卫生—药剂学]
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国际流行病学传染病学杂志
2021年 第1期

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