幽门螺旋杆菌感染对妊娠期糖尿病患者妊娠结局的影响

Effect of Helicobacter pylori infection on pregnancy outcome in patients with gestational diabetes mellitus

目的探究幽门螺旋杆菌(Hp)感染对妊娠期糖尿病(GDM)患者妊娠结局的影响。方法随机选取于我院门诊规律产检的妊娠妇女179例,根据OGTT试验结果,将其分为GDM组(66例)和对照组(113例)。所有入组孕妇于次日空腹抽静脉血检测Hp血清抗体,比较两组患者中Hp的感染率。GDM组患者根据检测结果再分为Hp阳性和Hp阴性组两个亚组,比较两亚组患者的妊娠结局。结果(1)对照组Hp的感染率为33.62%,GDM组为57.57%,GDM组Hp感染率高于对照组(P=0.002)。(2)在GDM患者中,Hp阳性组分娩孕周、孕末胎儿头围、腹围、新生儿体质量、身长显著低于Hp阴性组(P<0.05);Hp阳性组妊娠剧吐(HG)、子痫前期(PE)、早产、流产的发生率显著高于Hp阴性组(P<0.05)。结论GDM患者中Hp感染很常见,且较正常孕妇对Hp更易感,Hp感染可影响GDM患者的妊娠结局。

Objective To explore the effect of Helicobacter pylori(Hp)infection on pregnancy outcome in patients with GDM.Methods A total of 179 pregnant women having regular prenatal examinations in our hospital were randomly selected,then divided into GDM group(66 cases)and control group(113 cases)according to the screening results of OGTT.All pregnant women were tested for Hp serum antibodies by fasting venous blood in the next morning.The Hp infection rate of the two groups of patients was compared.GDM group was sub⁃divided into Hp positive group and Hp negative group.The pregnancy outcome of the Hp positive group and Hp negative group was compared.Results(1)Hp infection rate in GDM group was 57.57%,which was apparently higher than that in the control group of 33.62%(P=0.002).(2)In patients with GDM,gestational week of delivery,fetal head and abdominal circumference in pregnancy end,newborn weight and body length of Hp positive group were notably shorter or lower than these in Hp negative group(P<0.05).Incidence of hyperemesis gravidarum(HG),pre⁃eclampsia(PE),preterm birth and abortion in Hp positive group was significantly higher than that in Hp negative group(P<0.05).Conclusion Hp infection is prevalent in GDM patients,and GDM patients are more susceptible to Hp infection than normal pregnant women,which affects the pregnancy outcome of GDM patients.