血清铁蛋白及其与肝脏疾病的关系研究进展

Research progress of relationship between serum ferritin and hepatic disease

铁作为人体内重要的微量元素之一,参与多种重要的生理过程。血清铁蛋白(SF)是铁的主要贮存蛋白,可调节铁的储存和代谢。尽管铁蛋白检测已在临床应用较长时间,但其部分生物学特性如组织来源、分泌途径、受体相互作用及细胞效应等仍存在争议。虽然许多研究关注铁蛋白变化与肝脏疾病的关系,但各研究采纳的铁蛋白过高/过低阈值不尽相同,阻碍了对不同研究结果的一致性分析,亟需研究和制定铁蛋白参数的统一标准,以更好地阐明铁蛋白变化所反映的机体内铁状态。该文就铁的体内代谢过程,铁蛋白的结构及病理生理功能,以及SF与肝脏疾病关系的研究进展进行综述,以期为未来的研究提供导向。

As a crucial microelement of human body,iron is involved in many important physiological processes.Serum ferritin(SF)is the main form of protein for iron storage,and regulates the storage and metabolism of iron.Although detection of ferritin has been applied for clinical use for a long time,some biological properties of ferritin still remain controversial,including its tissue origin,secretory pathway,interactions with receptors and cellular effects.Although many researches paid attention to the relationship between the changes of ferritin and liver diseases,the cut-off points of ferritin used varies in different studies,which hinders the consistency analysis of the results of different studies.It is urgent to explore and establish uniform standard for the parameter of ferritin,so as to better elucidate the iron status in the body reflected by changes in ferritin.This paper reviews the in vivo metabolic process of iron,the structural composition and pathophysiological function of ferritin,and the relationship between SF and liver diseases for providing guidance for future research.