m^(6)A甲基化与乳腺癌

m^(6)A methylation and breast cancer

m^(6)A甲基化可以调节机体RNA的代谢,参与乳腺癌的发病过程。m^(6)A甲基转移酶、m^(6)A去甲基化酶、m^(6)A结合蛋白共同调节m^(6)A甲基化修饰的动态可逆过程。近年来研究显示甲基转移酶样蛋白(METTL)3、MELLT14、KIAA1429、去甲基化酶脂肪和肥胖相关蛋白、YTH结构域家族蛋白1~3等相关因子在乳腺癌中异常表达,可能通过调节m^(6)A甲基化和去甲基化过程影响乳腺癌的发生与发展,对其进行深入研究将为乳腺癌的临床诊治提供一个新的思路和靶点。

m^(6)A methylation can regulate RNA metabolism and participates in the pathogenesis of breast cancer.m^(6)A methyltransferase,demethylase and methylated binding protein regulate the dynamic and reversible process of m^(6)A methylation modification together.In recent years,studies have shown that methyltransferase-like(METTL)3,MELLT14,KIAA1429,fat-mass and obesity associated protein,YTH domain family member 1-3 and other related factors are abnormally expressed in breast cancer,which may affect the occurrence and development of breast cancer by regulating the methylation and demethylation process of m^(6)A.Further studies will provide a new idea and target for clinical diagnosis and treatment of breast cancer.