乳腺癌治疗中的心脏保护

Heart protection in the treatment of breast cancer

乳腺癌患者患心血管疾病的概率更高,年龄大、射血分数低、冠状动脉疾病史、心脏危险因素、蒽环类药物联合曲妥珠单抗或放疗均会增加治疗后发生心脏事件的风险。利用超声心动图监测心脏状况,特别是对有高血压、糖尿病、高脂血症和肥胖等传统心脏危险因素或左心室射血分数正常基线偏低的患者可降低心脏危险事件。在蒽环类药物治疗期间肌钙蛋白升高和早期心肌变形,可能预示着射血分数的降低,但需要进一步的研究来证明常规筛选和早期治疗的临床益处。对于乳腺癌患者,戒烟、定期锻炼、健康饮食和保持健康体重等,可降低患心血管疾病的风险。

Breast cancer patients have a higher risk of cardiovascular disease,older age,lower ejection fraction,history of coronary artery disease,cardiac risk factors,anthracycline combined with trastuzumab or radiotherapy will increase the risk of cardiac events after treatment.Echocardiographic monitoring the heart condition,especially for those patients with traditional heart risk factors such as hypertension,diabetes,hyperlipidemia and obesity or with low left ventricular ejection fraction at normal baseline,can reduce cardiac risk events.Elevated troponin and early myocardial deformation during anthracycline therapy may indicate a decrease in ejection fraction,but further studies are needed to prove the clinical benefits of routine screening and early treatment.For patients with breast cancer,smoking cessation,regular exercise,healthy diet and maintaining a healthy weight,etc.,can reduce the risk of cardiovascular disease.