姜黄素在2型糖尿病及其慢性并发症中作用及机制的研究进展

Advances in Research on Effects and Mechanisms of Curcumin on Type 2 Diabetes Mellitus and Its Chronic Complications

2型糖尿病(T2DM)是一种慢性代谢性疾病,长期高血糖导致各种并发症的发生,如肾病、心肌病等,姜黄素是中药姜黄中的活性成分,其抗氧化、抗炎、降血糖等活性使其在2型糖尿病及其慢性并发症治疗和预防中有很大的潜力。姜黄素可以延缓糖尿病的发展,改善β细胞功能,降低胰岛素抵抗等,笔者综述了姜黄素在T2DM及其慢性并发症中作用,探讨其改善T2DM的机制。

Type 2 diabetes mellitus(T2DM)is a chronic metabolic disease.High blood sugar can produce various complications,such as kidney disease and cardiomyopathy etc.Curcumin is a bioactive molecule presents in the Curcumae longae plant.Its antioxidant,anti-inflammatory and hypoglycemic activities make it have great potential in the treatment and prevention of the disease of T2DM.Research shows that curcumin delays the development of diabetes,improvesβ-cell functions and decreases insulin resistance.This paper reviewed the role of curcumin in T2DM and its chronic complications,and discussed the mechanism of curcumin in improving T2DM.