血液透析滤过的临床应用进展

Progress towards clinical applications of hemodiafiltration

终末期肾病(end stage renal disease,ESRD)是世界范围内重大的公共健康问题。血液透析滤过(hemodiafiltration,HDF)结合了扩散和对流的方法,可有效清除低分子量和中分子量溶质。随着透析膜材料、超滤控制系统和水处理技术的进步,HDF已成为一项方便、安全、成熟的治疗技术,最新的临床研究结果证实了HDF可能通过更有效的溶质清除和/或低温效应降低ESRD患者死亡率,改善预后。

End-stage renal disease(ESRD)is a global healthcare burden.Hemodiafiltration(HDF)is capable of effective clearance of solutes of low and middle molecular weight by combining diffusion and convection.With the improvement of dialyzer membrane and the progress of ultrafiltration control system and water treatment techniques,HDF is currently an accessible,safe and well-established treatment option.Latest clinical evidence demonstrated that HDF can reduce mortality of ESRD patients by superior solutes clearance and/or cooling effect.