运动疗法对维持性血液透析患者微炎症状态及高同型半胱氨酸血症的影响

Effects of exercise therapy on microinflammation and hyperhomocysteinemia in maintenance hemodialysis patients

目的探讨运动疗法对维持性血液透析(maintenance hemodailysis,MHD)患者微炎症状态及高同型半胱氨酸血症(hyperhomocysteinemia,HHcy)的影响。方法MHD患者90例,随机分成运动组和对照组,运动组血液净化期间进行卧位体操康复运动训练,每次20~35min,每周3次,共6个月,观察运动组和对照组运动6个月前、后的白介素-6(interleukin-6,IL-6)、降钙素原(procalcitonin,PCT)、C反应蛋白(C-reactive protein,CRP)、同型半胱氨酸(homocysteine,Hcy)水平的变化情况。结果运动6个月后,运动组IL-6、PCT、CRP、Hcy水平较对照组下降,差异有统计学意义(P<0.05);运动组运动6个月后IL-6、PCT、CRP、Hcy水平较运动前下降(t值分别为2.807,2.668,3.042,2.072;P值分别为0.006,0.009,0.001,0.042)。结论血液净化期间运动疗法对MHD患者微炎症状态及HHcy有改善作用。

Objective To investigate the effects of exercise therapy on microinflammatory status and hyperhomocysteinemia(HHcy)in maintenance hemodialysis(MHD)patients.Methods A total of 90 MHD patients were enrolled in this study.They were randomly divided into exercise group and control group.Patients in the exercise group performed an intradialytic exercise program for 20~35 minutes during the first 2 hours in a dialysis session,and the intradialytic exercise was carried out 3 dialysis sessions per week for 6 months.Serum interleukin-6(IL-6),procalcitonin(PCT),C-reactive protein(CRP)and homocysteine(Hcy)levels were measured in both groups before the treatment and after the treatment for 6 months.Results The levels of IL-6,PCT,CRP and Hcy in the exercise group were lower than those in the control group after 6 months,and the differences were statistically significant(P<0.05).In the exercise group,the levels of IL-6,PCT,CRP and Hcy decreased after 6 months of exercise compared with those before exercise,and the differences were statistically significant(P<0.05).Conclusions Intradialytic exercise therapy had significant effects on microinflammation and HHcy in MHD patients.