极低出生体质量儿胎粪钙卫蛋白水平及影响因素分析

Meconium calprotectin level and its influencing factors in very low birth weight infants

目的了解极低出生体质量儿胎粪钙卫蛋白(FC)水平及其影响因素。方法收集2018年6月—2019年5月住院的极低出生体质量儿出生后第1次胎粪,采用免疫荧光法定量检测胎粪钙卫蛋白水平,并收集患儿一般资料及母孕期资料。结果共纳入87例极低出生体质量儿,男45例、女42例,中位胎龄30.3周(29.1~31.1周),中位出生体质量1300 g(1200~1450 g),中位胎粪钙卫蛋白水平165.1μg/g(57.4~408.2μg/g)。孕妇产前合并先兆子痫及胎儿宫内窘迫组相较未合并组,胎粪FC水平明显升高,差异有统计学意义(P<0.05)。根据生后有无合并喂养不耐受将87例极低出生体质量儿分成病例组(38例)和对照组(49例),两组间胎粪钙卫蛋白水平差异无统计学意义(P>0.05)。结论极低出生体质量儿胎粪钙卫蛋白水平高,个体波动大;孕妇产前合并先兆子痫及胎儿宫内窘迫对极低出生体质量儿生后的胎粪钙卫蛋白水平有影响。

Objective To explore the fecal calprotectin(FC)level in meconium and its influencing factors in very low birth weight infants.Methods The first meconium after birth in very low birth weight infants hospitalized from June 2018 to May 2019 was collected.Immunofluorescence method was performed to detect quantitatively the FC levels in meconium,and general data during maternal pregnancy and infancy were collected.Results A total of 87 very low birth weight infants(45 boys and 42 girls)were included.The median gestational age was 30.3 weeks(29.1~31.1),the median birth weight was 1300 g(1200~1450),and the median FC level in meconium was 165.1(57.4~408.2)μg/g.The FC level in meconium in the group of pregnant women with preeclampsia and fetal distress was significantly higher than that in the group of pregnant women without preeclampsia(P<0.05).Eighty-seven very low birth weight infants were divided into case group(n=38)and control group(n=49)according to whether they had feeding intolerance after birth,and there was no significant difference in meconium FC levels between the two groups(P>0.05).Conclusion The meconium FC level in very low birth weight infants is high,and widely varies among individuals.Prenatal complications of preeclampsia and intrauterine distress may influence meconium FC levels in very low birth weight infants.