2011—2017年上海市金山区疑似预防接种异常反应监测结果分析

Surveillance data analysis of suspected adverse events following immunization in Jinshan district of Shanghai,2011—2017

目的分析上海市金山区2011—2017年疑似预防接种异常反应(adverse events following immunization,AEFI)的发生特征,评价疫苗的安全性,为进一步完善AEFI监测工作提供依据。方法通过中国AEFI信息管理系统和上海市免疫规划信息系统,收集2011—2017年上海市金山区AEFI个案信息和疫苗接种信息,采用描述流行病学方法进行分析。结果 2011—2017年金山区报告AEFI个案3 023例,报告发生率为168.50/10万剂,其中一般反应2 954例,占97.72%;异常反应64例,占2.12%;偶合反应5例,占0.16%;无疫苗质量事故、接种事故和心因性反应报告。AEFI的男女性别比1.20∶1;发生年龄主要集中在≤2岁组,占78.84%;夏、秋季发生分别占27.18%、33.38%;AEFI 92.25%发生在接种当天。一般反应以发热和局部红肿硬结为主,异常反应以过敏性皮疹为主,且发生率极低。结论上海市金山区AEFI监测系统敏感性逐步提高,疫苗不良反应报告发生率在预期发生范围内。

Objective To analyze the characteristics of suspected adverse events following immunization(AEFI)in Jinshan district of Shanghai in 2011—2017,to assess the safety of vaccines,and to provide evidence for further improvement of AEFI monitoring work.Methods Data of individual case of AEFI in Jinshan district of Shanghai in 2011—2017 were retrieved from AEFI information system of China,and vaccination records were acquired from Shanghai immunization program information system.A descriptive epidemiological method was used for data analysis.Results A total of 3023 cases of AEFI were reported in Jinshan district of Shanghai between 2011 and 2017 with the incidence of 168.50 per 100000 doses.Among them,2954(97.72%)cases had common adverse reactions,64(2.12%)had rare adverse reactions and 5(0.16%)had coincidental reactions.No vaccine quality events,inoculation accidents,psychogenic reactions and clustered AEFI were reported.The male to female ratio was 1.20∶1 and 78.84%were children of≤2 year old.27.18%cases occurred in summer and 33.38%in autumn.92.25%occurred within 1 day after vaccination.The most common vaccine reactions were fever,local swelling and induration.The most common rare vaccine reaction was anaphylactic rash,the incidence of serous rare vaccine reaction was very low.Conclusions The sensitivity of AEFI surveillance system in Jinshan District improves gradually with reasonable reported AEFI rate.