拉贝洛尔联合维生素D对妊娠高血压综合征患者血清25-(OH)DIG-FBP-1水平及母婴结局的影响

The effect of labetalol combined with vitamin D on serum 25-(OH)D and IGFBP-1 levels and maternal and infant outcomes in patients with pregnancy-induced hy-pertension

目的 探讨拉贝洛尔联合维生素D对妊娠高血压综合征患者血清25-二羟基维生素D、胰岛素样生长因子结合蛋白-1水平及母婴结局的影响.方法 将93例妊娠高血压综合征患者按就诊顺序分为3组,各31例.3组均予以硫酸镁治疗,在此基础上,对照A组予以拉贝洛尔治疗,对照B组予以维生素D治疗,观察组予以拉贝洛尔联合维生素D治疗,观察1周.比较3组血压控制情况(收缩压、舒张压)、炎性因子(血清肿瘤坏死因子α、C反应蛋白)、血清25-二羟基维生素D、胰岛素样生长因子结合蛋白-1水平,统计不良反应发生状况及母婴结局.结果 治疗后,观察组收缩压、舒张压及血清肿瘤坏死因子α、C反应蛋白水平显著低于对照A组、B组(P<0.01),血清25-二羟基维生素D、胰岛素样生长因子结合蛋白-1水平显著高于对照A组、B组(P<0.01).观察组自然分娩率显著高于对照A组、B组(P<0.05);3组不良反应及新生儿窒息发生率比较差异无统计学意义(P>0.05).结论 拉贝洛尔联合维生素D能显著降低妊娠高血压综合征患者血压,减轻炎症反应,提高血清25-二羟基维生素D、胰岛素样生长因子结合蛋白-1水平,改善母婴结局.

Objective To investigate the effects of labetalol combined with vitamin D on serum 25-(OH)D and IGFBP-1 levels and maternal and infant outcomes in patients with pregnancy induced hypertension.Methods 93 patients with pregnancy-induced hypertension were divided into 3 groups,31 cases in each group.The 3 groups were all treated with magnesium sulfate.On this basis,the control group A was treated with labetalol,the control group B was treated with vitamin D,and the observation group was treated with labetalol for 1 week.The blood pressure control status(systolic blood pressure,diastolic blood pressure),inflammatory factors(TNF-a,CRP),serum 25-(OH)D,IGFBP-1 levels were compared.among the three groups,and the incidence of adverse reactions and maternal and infant outcomes were counted.Results After treatment,the DBP and SBP in the observation group and serum TNF-a,CRP levels were significantly lower than those of the control group A and B(P<0.01),and the serum 25-(OH)D and IGFBP-1 levels were significantly higher than the control group A and B(P<0.01).The nat-ural delivery rate of the observation group was significantly higher than that of the control groups A and B(P<0.05).There was no significant difference in the incidence of adverse reactions and neonatal asphyxia in the three groups(P>0.05).Conclusions The application of vitamin D assisted labetalol in patients with pregnancy-induced hypertension can significantly lower blood pressure,reduce inflammation,increase serum 25-(0H)D,IGFBP-1 levels,and improve maternal and infant outcomes.