肺表面活性物质不同给药方法对新生儿肺透明膜病血气指标及预后的影响

Effect of different administration methods of pulmonary surfactant on blood gas indexes and prognosis of neonatal hyaline membrane disease

目的 探讨肺表面活性物质不同给药方法对新生儿肺透明膜病血气指标及预后的影响.方法 将116例新生儿肺透明膜病患儿随机分为两组,每组58例.两组均予以常规吸痰、吸氧、营养支持、抗感染等基础治疗,在此基础上对照组采用传统给药方法予以肺表面活性物质治疗,观察组采用改良给药方法予以肺表面活性物质治疗,比较两组的临床疗效、血气指标及预后情况.结果 观察组总有效率显著高于对照组(P<0.05),并发症发生率显著低于对照组(P<0.05).治疗后观察组血氧分压-肺泡氧分压、氧分压、二氧化碳分压、pH值均较治疗前显著改善(P<0.01),观察组显著优于对照组(P<0.05或0.01).观察组给药时间及住院时间均显著短于对照组(P<0.01).结论 与传统给药方法相比,肺表面活性物质改良给药方法治疗新生儿肺透明膜病能提高疗效,改善患儿血气指标,减少并发症的发生,促进患儿康复.

Objective To study the effect of different hdministration methods of pulmonary surfactant on blood gas indexes and prognosis of neonatal hyaline membrane disease.Methods 116 cases of neonatal hy-aline membrane disease were randomly divided into two groups,58 cases each.Both groups were given basic treatments such as conventional sputum suction,oxygen inhalation,nutritional support,and anti-in-fection.On this basis,the control group was treated with pulmonary surfactants by traditional administra-tion methods.The observation group was treated with pulmonary surfactants by a modified administration method,and the clinical efficacy,blood gas indicators and prognosis of the two groups were compared.Results The total effective rate of observation group was significantly higher than that of control group(P<0.05),and the complication rate was significantly lower than that of control group(P<0.05).After treatment,the observation group's blood oxygen partial pressure-alveolar oxygen partial pressure,oxygen partial pressure,carbon dioxide partial pressure,and pH were significantly improved compared with be-fore treatment(P<0.01),and the observation group was significantly better than the control group(P<0.05 or 0.01)。The administration time and hospital stay in the observation group were significantly shor-ter than those in the control group(P<0.01).Conclusions Compared with the traditional non-essential methods,the improved administration method of pulmonary surfactants in the treatment of neonatal hya-line membrane disease can improve the curative effect,improve the blood gas indicators of the children,reduce the occurrence of complications,and promote the recovery of the children.