经纤维支气管镜局部给药对耐多药肺结核病的治疗研究

Treatment of multi-drug resistant tuberculosis by partial drug delivery of fiberoptic bronchoscope

目的研究耐多药肺结核患者采用纤维支气管镜局部给药治疗的临床疗效。方法选取2014年1月至2017年5月在本院接受治疗的90例耐多药肺结核患者,随机分为参照组和实验组,每组45例。两组均接受常规药物化学治疗,实验组在此基础上采用纤维支气管镜进行局部给药治疗。比较两组不良反应发生率和治疗效果。结果治疗6个月及治疗1年后实验组痰菌转阴率为66.67%、88.89%,均明显高于参照组的44.44%、71.11%,差异有统计学意义(P<0.05)。治疗6个月和1年后,实验组病灶吸收率均显著高于参照组(P<0.05)。实验组不良反应发生率(11.11%)低于参照组(28.89%),差异有统计学意义(P<0.05)。结论在耐多药肺结核患者的临床治疗中,纤维支气管镜局部给药的治疗效果较佳,患者的不良反应少,值得推广应用。

Objective To study the clinical effect of partial drug delivery of fiberoptic bronchoscope in patients with multi-drug resistant tuberculosis.Methods 90 patients with multi-drug resistant tuberculosis who were treated in our hospital from January 2014 to May 2017 were selected and randomly divided into control group and experimental group,with 45 cases in each group,two groups of patients were treated with conventional chemotherapy,the experimental group using partial drug delivery of fiberoptic bronchoscope on the basis of chemotherapy.Compared the adverse reactions and treatment effect of the two groups.Results After treated for six months and one year,the sputum conversion rates of the experimental group(66.67%,88.89%)were significantly higher than that of the control group(44.44%,71.11%),the difference was statistically significant(P<0.05).After six month and 1 year of treatment,the focal absorption rate of the experimental group were significantly higher than that of the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions(11.11%)in the experimental group was lower than that in the control group(28.89%),the difference was statistically significant(P<0.05).Conclusion In the clinical treatment of patients with multidrug resistant tuberculosis,the effect of partial drug delivery of fiberoptic bronchoscope is better and the adverse reactions of patients are less.