甲泼尼龙冲击治疗睡眠期癫痫性电持续状态患儿临床疗效及对智力水平的影响

Clinical efficacy of methylprednisolone in the treatment of children with electrical status epilepticus during sleep and its influence on intelligence level

目的探讨甲泼尼龙冲击治疗睡眠期癫痫性电持续状态患儿临床疗效及对智力水平的影响.方法将72例睡眠期癫痫性电持续状态患儿按单双号法分为冲击组与对照组,各36例.两组均给予抗癫痫药物治疗,冲击组在此基础上给予甲泼尼龙冲击治疗,比较两组患儿临床疗效、脑电图改善情况、韦氏儿童智力量表评分及不良反应发生率.结果冲击组临床治疗总有效率及脑电图改善总有效率均显著高于对照组(P<0.05).干预后两组韦氏儿童智力量表类同、填图两项因子分及总分均较治疗前显著升高(P<0.05),冲击组较对照组升高更显著(P<0.05).冲击组不良反应发生率显著高于对照组(P<0.05).结论甲泼尼龙冲击治疗能显著提高睡眠期癫痫性电持续状态患儿的临床疗效及智力水平,值得临床推广应用.

Objective To explore the effect of methylprednisolone in the treatment of children with electrical status epilepticus during sleep and its influence on intelligence level.Methods 72 children patients with ESES were randomly divided into shock group and control group according to the single and double number method,36 cases each.Both groups were treated with antiepileptic drugs,and the shock group was given methylprednisolone shock treatment on this basis.The clinical efficacy,EEG improvement,Wechsler Intelligence Scale and adverse reactions were compared between the two groups.Results The total effective rate of clinical treatment and total effective rate of EEG improvement in shock group were significantly higher than those in control group(P<0.05).After intervention,the scores of affinity and charting and the total score in WISC in both groups were significantly higher than those before treatment(P<0.05).The shock group was more significantly increased than the control group(P<0.05).The incidence of adverse reactions in the shock group was significantly higher than that in the control group(P<0.05).Conclusions Methylprednisolone shock therapy can significantly improve the clinical efficacy and intelligence level of children with ESES,which is worthy of clinical application.