甲基化修饰与支气管哮喘的研究进展

Research of methylation in bronchial asthma

支气管哮喘(哮喘)是一种慢性气道炎症性疾病,遗传、环境及免疫因素均参与其发病,表观遗传学充当媒介将三者联系起来,影响哮喘的发生、发展。甲基化修饰作为哮喘中常见的表观遗传学修饰,能通过不同机制参与哮喘的发病。本文回顾性分析近年相关文献,主要从作用机制及潜在治疗方面,阐述甲基化修饰与哮喘的关系。

Bronchial asthma(asthma)is a chronic inflammatory airway disease,with heredity,environment and immune factors involved in its pathogenesis.Epigenetics acts as a medium to link these factors resulting in the occurrence and development of asthma.As a common epigenetic modification in asthma,methylation can participate in the pathogenesis of asthma through different mechanisms.This paper reviews and analyzes the relevant literature in recent years,mainly from the mechanism and potential treatment,to explain the relationship between methylation and asthma.