北京社区人群高尿酸血症患病率与肥胖关系的研究

Study on the relationship between hyperuricemia and obesity in Beijing community population

目的探讨北京社区人群高尿酸血症(HUA)患病率与肥胖的关系。方法选取2013年6月至2014年9月于北京市平谷区采用随机抽样法对4002名25~75岁常住居民进行代谢性疾病调查。采用问卷调查、体格检查及化验检查收集一般资料及相关数据,分析HUA患病率与肥胖的关系。结果纳入人群HUA总患病率为7.9%,男性高于女性(11.0%vs 4.9%,P<0.01),40.9%为超重,28.7%为肥胖。HUA、超重及肥胖患病率呈性别和年龄特异性分布,男性HUA患病率在青壮年(25~35岁)达到峰值,之后呈降低趋势,女性更年期后患病率升高,甚至超过男性。HUA患病率随BMI升高而增加(2.7%vs 7.3%vs 14.4%,P<0.01),BMI与血尿酸(SUA)呈正相关(r=0.162,P<0.01)。结论北京平谷地区HUA总患病率为7.9%,HUA患病率随BMI升高而增加,BMI与SUA呈正相关。

Objective To investigate the epidemiological characteristics of hyperuricemia(HUA)in community-based populations and to explore the correlation between HUA and obesity.Methods During Jun 2013 to Sep 2014,a random sampling method was used to study metabolic diseases in Pinggu district of Beijing,China.The survey population was long-term residents aged 25~75 years old.Questionnaires,physical examinations and laboratory tests were used to collect general data,disease history and metabolic disease biomarkers.This study analyzes the epidemiological characteristics of HUA and its relationship with obesity.Results The total prevalence of HUA was 7.9%,which was higher in males than females(11.0%vs 4.9%,P<0.01).40.9%were overweight and 28.7%were obese in this cohort.The preva-lence of HUA and overweight/obesity were gender and age-specific.The prevalence of HUA in male reached its peak in young adults(25~35 years old),and then showed a downward trend.The prevalence rate of HUA in female increased after menopause or even exceeded that in male.The prevalence of HUA increased with BMI(2.7%vs 7.3%vs 14.4%,P<0.01),BMI was positively correlated with serum uric acid(SUA)(r=0.162,P<0.01).Conclusion The total prevalence of HUA in Pinggu district of Beijing was 7.9%.The prevalence of HUA increased with the increase of BMI.BMI was positively corre-lated with SUA.