敞开式电离质谱技术在法医毒物分析中的应用

Application of Ambient Ionization Mass Spectrometry in Forensic Toxicological Analysis

敞开式电离质谱(Ambient ionization mass spectrometry,AIMS)是指在大气压环境下,无需或只需简单的样品前处理即可对样品中目标物进行分析的质谱技术。AIMS具有简单、快速、无损和适用范围广等优势,被广泛应用于法医毒物分析领域。该文对敞开式电离(Ambient ionization,AI)技术进行了简单概述,将检材分为体内检材和体外检材两大类,综述了AIMS技术在不同类型检材毒物分析中的应用,并对其在法医毒物分析中的发展前景进行了展望。

Ambient ionization mass spectrometry(AIMS)is a mass spectrometry technology which could be used to analyze target analytes in samples under atmospheric pressure without or with simple sample pretreatment.With the advantages of simplicity,rapidness,non-destructiveness and wide application range,it is widely used in forensic toxicological analysis.This article gives a brief overview on the ambient ionization(AI)technique,and the samples are divided into two types:in vivo test materials and in vitro test materials.The application of AIMS in the poison analysis of different types of test materials is summarized,and its application direction in forensic toxicological analysis is prospected.