中药质量评价关键问题与分析方法探讨

Discussion on Key Problems for Quality Evaluation of Traditional Chinese Medicines and Their Analysis Methods

该文针对我国目前中药质量评价体系现状,总结了中药质量评价的关键科学问题,并围绕“发现”与“控制”有效成分的中药质量评价方法进行探讨。笔者结合多年中药质量分析研究工作经验,分析了中药“谱-效”关系研究、全时段等基线多波长融合指纹图谱、生物活性测定法3种质量评价与检测方法的研究内容、手段、适用范围等,为丰富、完善中药质量控制方法和中药质量标准体系的提升提供了借鉴。

In view of current situation for the quality evaluation system of traditional Chinese medicine(TCM),the key scientific problems for TCM quality evaluation are summarized.The methods for quality evaluation of TCM based on“discovery”and“control”effective ingredients are mainly discussed in this paper.Combined with the author′s years of experience in quality analysis and research of TCM,the research contents,means and application scopes of three quality evaluation and detection methods are analyzed,including“spectrum-effect”relationship research,multi-wavelength fusion fingerprint and biological activity determination,so as to provide a reference for enriching and improving the quality control methods and quality standard system of TCM.