哌甲酯与托莫西汀在注意缺陷多动障碍患儿治疗中效果及安全性比较

Comparison of efficacy and safety of methylphenidate and tomoxetine in the treatment of children with attention deficit hyperactivity disorder

目的通过对比哌甲酯,探讨托莫西汀在注意缺陷多动障碍(ADHD)患儿治疗中效果及安全性。方法抽取2017年6月~2019年6月间确诊并收治86例ADHD患儿作为研究对象,按照双色球法随机分为两组,给予对照组患儿盐酸哌甲酯缓释片口服治疗,给予研究组患儿盐酸托莫西汀胶囊口服治疗,均连续治疗8周,评估两组治疗方案疗效,并记录治疗期间患儿药物不良反应情况。结果治疗后两组ADHD患儿SNAP-IV量表及Conners儿童行为问卷各项评分均较治疗前显著降低,但组间差异并无统计学意义(P> 0.05),且两组方案连续治疗8周疗效(44.19%vs.39.53%)差异并无统计学意义(P> 0.05)。但研究组药物不良反应发生率显著低于对照组(23.26%vs. 39.53%),差异有统计学意义(P <0.05)。结论在ADHD患儿治疗中应用托莫西汀进行治疗,可以取得媲美于哌甲酯的治疗效果,且治疗期间不良反应较低,安全性较高。

Objective To compare the efficacy and safety of tomoxetine in the treatment of children with attention deficit hyperactivity disorder(ADHD)by comparing methylphenidate.Methods From June 2017 to June 2019,86 cases of ADHD patients diagnosed and treated in our hospital were selected as the research object.They were randomly divided into two groups according to the two-color ball method,and the control group was given oral methylphenidate hydrochloride sustained-release tablets.Tomoxetine hydrochloride capsules were given to the children in the study group for oral treatment for 8 consecutive weeks.The therapeutic effects of the two groups were evaluated,and the side effects of drugs during the treatment were recorded.Results After treatment,the scores of SNAP-IV scale and Conners Child Behavior Questionnaire of ADHD children in two groups were significantly lower than before treatment,but the difference between the groups was not statistically significant(P>0.05),and the two groups the 8-week efficacy of(44.19%vs.39.53%)was not statistically significant(P>0.05).However,the incidence of adverse drug reactions in the study group was significantly lower than that in the control group(23.26%vs.39.53%)(P<0.05).Conclusion The application of tomoxetine in the treatment of children with ADHD can achieve a therapeutic effect comparable to methylphenidate,and the adverse reactions during treatment are low and the safety is high.