阿帕替尼联合紫杉醇及顺铂化疗对晚期非小细胞肺癌PFS及T细胞亚群的影响

Effects of apatinib combined with paclitaxel and cisplatin chemotherapy on PFS and T cell subsets in advanced non-small cell lung cancer

目的分析阿帕替尼联合紫杉醇及顺铂化疗对晚期非小细胞肺癌(NSCLC)患者中位无进展生存(PFS)及T细胞亚群的影响。方法本次主要选取2018年8月~2019年8月期间收治的晚期非小细胞肺癌患者80例,按照不同化疗方法分为对照组与研究组,对照组患者采取紫杉醇及顺铂常规化疗方案;研究组患者则在对照组基础上加以阿帕替尼进行联合治疗。对比两组患者临床疗效、PFS以及T细胞亚群的变化情况。结果治疗后两组患者T细胞亚群[CD3^(+)、CD4^(+)/CD8^(+)、自然杀伤细胞(NK)]各项水平均降低,但研究组降低幅度更明显,差异有统计学意义(P<0.05);研究组患者疗效明显优于对照组患者(P<0.05);研究组中位PFS 5.5个月比对照组5.1个月略长,但差异无统计学意义(χ^(2)=0.446,P>0.05)。结论晚期非小细胞肺癌患者,予以阿帕替尼联合紫杉醇及顺铂化疗方案治疗可有效提高患者免疫功能,临床效果突出。

Objective Effects of apatinib combined with paclitaxel and cisplatin chemotherapy on median progression-free survival(PFS)and T cell subsets in patients with advanced non-small cell lung cancer(NSCLC).Methods This investigation and analysis mainly selected 80 patients with advanced non-small cell lung cancer treated in our hospital from August 2018 to August 2019.They were divided into control group and study group according to different chemotherapy methods.The patients in the control group were treated with paclitaxel and conventional chemotherapy regimens of cisplatin;patients in the study group were treated with apatinib in combination with the control group.The clinical efficacy,PFS and T cell subsets were compared between the two groups.Results After treatment,the levels of T cell subgroups[CD3^(+)、CD4^(+)/CD8^(+),natural killer cells(NK)]in the two groups decreased,but the reduction was more significant in the study group,and the difference was statistically significant(P<0.05);The curative effect of the patients in the study group was significantly better than that of the control group(P<0.05);the median PFS of 5.5 months in the study group was slightly longer than the 5.1 month in the control group,but the difference was not significant(χ^(2)=0.446,P>0.05).Conclusion In patients with advanced non-small cell lung cancer,treatment with apatinib combined with paclitaxel and cisplatin chemotherapy can effectively improve the immune function of patients,and the clinical effect is outstanding.