聚集诱导发光材料在光学诊疗中的研究进展

Recent Advances of Aggregation-induced Emission Materials in Phototheranostics

光学诊疗是一种利用光激活的激发态能量转化效应实现疾病诊断和同时原位治疗的新型诊疗模式,它具有时空选择性高、毒副作用低、疗效好和可控性强等优点,在疾病诊疗中展现了巨大的应用潜力。近些年,得益于其生物安全性好、光物理性质可调、易于合成和功能化修饰、出色的荧光和光敏性能、以及可便于构筑多模态诊疗试剂等优势,聚集诱导发光材料在光学诊疗领域取得了重大突破进展。基于此,本文从如何通过精准分子设计以及调控分子在聚集态下的运动构筑高效的聚集诱导发光光诊疗体系出发,从荧光成像指导的光动力治疗、光声成像指导的光热治疗和多模态成像指导的协同治疗三个方面总结了聚集诱导发光材料在光学诊疗领域的最新研究进展,并对其未来的发展方向与前景进行了展望。

Phototheranostics involving the ingenious integration of light-triggered diagnostics and therapeutics has been recognized to be potentially powerful for disease treatment as it provides high temporal and spatial selectivity,low side effects,high therapeutic effectiveness and controllability.Benefiting from the appreciable biosafety,tuneable photophysical properties,facile processability and functionalization,excellent fluorescence and photosensitizing performances,as well as the feasibility in building multimodal phototheranostic agents,luminogens with aggregation-induced emission(AIE)nature have achieved great breakthrough in the field of phototheranostics over the past few years.This review summarizes the state-of-the-art advancements of AIE luminogens in phototheranostic applications mainly referring to fluorescence imaging-guided photodynamic therapy,photoacoustic imaging-guided photothermal therapy,and multimodal imaging-guided synergistic therapy on the basis of the precise molecular engineering and subtle regulation of molecular aggregation behaviors.Additionally,a brief conclusion and perspectives for the future of this field are also presented at the end of this review.