清肠愈疡汤口服及中药灌肠对溃疡性结肠炎患者血清I-FABP、sRAGE和p-ANCA水平的影响

Effects of Oral Administration of Qingchang Yuyang Decoction and Herbal Enema on the Levels of Serum I-FABP,sRAGE and p-ANCA in UC Patients

目的:观察清肠愈疡汤口服及中药灌肠联合美沙拉嗪治疗溃疡性结肠炎的临床疗效及其对血清肠型脂肪酸结合蛋白(intestinal fatty acid binding protein,I-FABP)、可溶性晚期糖基化终末产物受体(soluble receptor for advanced glycation endproducts,sRAGE)和核周型抗中性粒细胞抗体(perinuclear antineutrophil cytoplasmic antibody,p-ANCA)水平的影响。方法:将溃疡性结肠炎患者124例根据随机数字表法分为观察组和对照组各62例。对照组予美沙拉嗪治疗,观察组在对照组基础上予清肠愈疡汤口服和中药灌肠治疗。观察两组临床疗效及治疗前后临床症状评分、肠镜下黏膜评分、Sutherland DAI评分、组织病理评分,并观察全血黏度及I-FABP、sRAGE和p-ANCA水平变化情况。结果:总有效率观察组为95.2%(59/62),高于对照组的80.6%(50/62)(χ^(2)=4.854,P<0.05)。治疗后两组患者临床症状评分、肠镜下黏膜评分、Sutherland DAI评分、组织病理评分、全血黏度及I-FABP、sRAGE和p-ANCA水平均较治疗前降低(P<0.01),观察组降低更明显(P<0.01)。结论:清肠愈疡汤口服及中药灌肠联合美沙拉嗪能促进溃疡性结肠炎患者结肠黏膜损伤愈合,降低血液黏度,其机制可能与降低血清I-FABP、sRAGE和p-ANCA水平有关。

Objective:To observe clinical effects of oral administration of Qingchang Yuyang decoction and herbal enema combined with mesalazine in treating ulcerative colitis(UC),and its influence on the levels of I-FABP,sRAGE and p-ANCA.Methods:All 124 UC patients were allocated to the observation group and the control group according to random number table method,62 cases each group.The control group were treated by mesalazine,the observation group by oral administration of Qingchang Yuyang decoction and herbal enema on the foundation of Western medicine.To observe clinical effects,clinical symptom integrals,endoscopic submucosal score,Sutherland DAI scores and histopathological score before and after treating between both groups,to observe the levels of whole blood viscosity,I-FABP,sRAGE and p-ANCA.Results:Total effective rate of the observation group was 95.2%(59/62),higher than 80.6%(50/62)of the control group(χ^(2)=4.854,P<0.05).After treating,clinical symptom integrals,endoscopic submucosal score,Sutherland DAI scores and histopathological score,the levels of whole blood viscosity,I-FABP,sRAGE and p-ANCA of both groups lowered than before treating(P<0.01),the decrease of the observation group was more notable(P<0.01).Conclusion:Oral administration of Qingchang Yuyang decoction and herbal enema combined with mesalazine could promote the healing of colonic mucosal injury and lower blood viscosity in treating UC patients,and its mechanism might be related to lowering the levels of I-FABP,sRAGE and p-ANCA.