血红蛋白与红细胞分布宽度比值在胃癌筛查中的价值

The value of the ratio of hemoglobin to red cell distribution width in the screening of gastric cancer

目的:探讨血红蛋白(Hb)与红细胞分布宽度(RDW)比值(HRR)在胃癌筛查中的应用价值。方法:收集2019年1月〜12月的胃癌组患者150例、其它癌症组患者131例、胃良性病变组患者136例和健康体检组126例,采用雅培ARCHITECT i2000仪器检测以上各组患者的血清糖类抗原199(CA199)和癌胚抗原(CEA),Sysmex血液分析仪检测Hb和RDW,并计算出二者比值HRR。结果:CA199、CEA、RDW和HRR的检测结果在胃癌组、其它癌症组、胃良性病变组和健康体检组间具有显著性差异(P<0.05),经多重比较显示,仅HRR具有显著性差异(P<0.05)。ROC曲线分析显示,CA199、CEA、RDW和HRR的曲线下面积分别为0.565、0.767、0.628和0.868,HRR敏感性和特异性分别为87.3%和72.0%,对各指标的曲线下面积进行比较,仅CA199与RDW比较无显著差异性(z=1.467,P=0.142),其余各指标的AUC比较均有显著差异性(P<0.05)。结论:血红蛋白与红细胞分布宽度比值在胃癌筛查中有一定的应用价值,可提高胃癌早期的检出率。

Objective:To explore the application value of the ratio of hemoglobin to red cell distribution width in gastric cancer screening.Methods:150 gastric cancer patients,131 patients with other cancer,136 benign gastric disease patients and 126 healthy controls were collected from January to December 2019.ARCHITECT i2000 was used to detecting CA199 and CEA levels in all patients and healthy controls,Hb and RDW levels were measured by Sysmex blood analyzer,and then calculate HRR.Results:Statistical significance(P<0.05)were found for the serum levels of four indexes in gastric cancer patients group,other cancer patientsgroup,benign gastric disease patientsgroup,healthy controls group were different.After multiple comparison between groups,only HRR had significant difference(P<0.05).ROC curve analysis showed that the area under the curve of CA199,CEA,RDW and HRR was 0.565,0.767,0.628 and 0.868,respectively.The sensitivity and specificity of HRR were 87.3% and 72.0%,respectively.The was no significant difference between CA199 and RDW(z=1.467,P=0.142),and the other indicators AUC had significant difference(P<0.05).Conclusion:The ratio of hemoglobin to red cell distribution width has value in the screening of gastric cancer,maybe it can improve the positive rate of early gastric cancer.