妊娠压力在产妇产后抑郁和认知功能状况之间的中介效应

Intermediate effect of pregnancy pressure on postpartum depression and cognitive impairment in parturients

目的探讨妊娠压力在产妇产后抑郁和认知功能之间的中介效应。方法选取2018年10月~2019年4月在唐山市第三医院妇产科自然分娩的330例产妇为研究对象。应用蒙特利尔认知评估量表(MoCA)评价产妇的认知功能状况;应用爱丁堡产后抑郁量表(EPDS)评价产妇产后抑郁状况;应用妊娠压力量表(PPS)评价产妇妊娠期特殊压力状况。对三者关系进行相关性分析和中介效应分析。结果330例产妇妊娠压力得分为(0.91±0.51)分;产后抑郁得分为(6.15±3.76)分,认知功能得分(24.99±1.52)分;Pearson相关分析结果为,产妇妊娠压力与产后抑郁(r=0.664,P<0.001)呈正相关;妊娠压力与认知功能状况(r=-0.652,P<0.001)呈负相关;而产妇产后抑郁与认知功能状况(r=-0.427,P<0.001)呈负相关。中介效应结果显示,妊娠压力在产妇产后抑郁与认知功能状况之间是中介效应(P<0.001),中介效应值为0.943。结论产妇产后抑郁对认知功能状况的影响作用部分是通过其妊娠压力的中介作用实现的。

Objective To explore the mediating effect of pregnancy stress on postpartum depression and cognitive function.Methods 330 women who were born naturally in obstetrics and gynecology in the Third Hospital of Tangshan City from October 2018 to April 2019 were selected as the subjects.The montreal cognitive assessment scale(MoCA)was used to evaluate maternal cognitive function status;The edinburgh postnatal depression scale(EPDS)was used to evaluate maternal postpartum depression status;The pregnancy stress scale(PPS)was used to evaluate maternal special stress status during pregnancy.Correlation analysis and intermediary effect analysis of the three relationships.Results 330 births pregnancy stress score(0.91±0.51);Postpartum depression score(6.15±3.76);Cognitive function score(24.99±1.52);Pearson correlation analysis showed positive correlation with postpartum depression(r=0.664,P<0.001);Maternal pregnancy stress was negatively correlated with maternal cognitive function(r=-0.652,P<0.001);And maternal postpartum depression was negatively correlated with maternal cognitive function(r=-0.427,P<0.001)was negatively correlated.Results of intermediary effect showed that pregnancy stress was a mediating effect between postpartum depression and cognitive function status status(P<0.001)with a mediating effect value of 0.943.Conclusion The effect of postpartum depression on cognitive function is partly achieved by mediating pregnancy stress.