液相色谱-串联质谱应用研究进展

Progress in the Application Study of Liquid Chromatography-Tandem Mass Spectrometry

液相色谱-串联质谱(Liquid chromatography-tandem mass spectrometry,LC-MS/MS)是由具有高效分离能力的液相色谱和具有高准确分析能力的质谱串联,实现化合物鉴定和定量的重要分析技术。随着先进仪器的研发和相关技术的发展,使得LC-MS/MS的分离分析能力更加强大。简单介绍了质谱仪的发展历史以及工作原理,对LC-MS/MS在食品安全、临床诊断、环境监测、生命科学和医学制药等领域的应用研究进展进行了综述,并对其发展趋势和应用前景进行了展望,以期为相关领域技术人员提供参考。

Liquid chromatography-tandem mass spectrometry(LC-MS/MS)is an essential analytical technique for the identification and quantification of compounds that combines high-efficiency separation capabilities of liquid chromatography with the high accuracy capabilities of mass spectrometry.With the development of advanced instruments and analytical methods,the separation and analysis capabilities of LC-MS/MS have become more powerful.This paper briefly introduces the development history and the working principles of the mass spectrometer,reviews the research progress of LC-MS/MS technology in food safety,clinical diagnosis,environmental monitoring,life sciences,and medical pharmacy,and related development trend and application prospects,to provide a reference for technicians in related fields.