咽喉反流病合并阻塞性睡眠呼吸暂停低通气综合征患者症状表现及治疗预后的影响

Clinical Symptoms and Prognostic Factors of Coexisting Laryngopharyngeal Reflux Disease and Obstructive Sleep Apnea Hypopnea Syndrome

目的:探讨咽喉反流病(LPRD)合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者症状表现及治疗预后的影响因素。方法:回顾性分析80例LPRD合并OSAHS患者的临床资料,依据患者出院后睡眠期间是否还存在咽喉反流情况分为预后良好组、预后不良组,收集两组入院后的基础资料信息。分析LPRD合并OSAHS患者症状表现,对比预后良好组及预后不良组的基础资料信息;将两组有差异信息纳入Logistic模型,行量化赋值,明确LPRD合并OSAHS患者预后不良的危险因素。结果:LPRD合并OSAHS患者临床症状多表现为咽异物感、鼻塞、气喘、上气道梗阻,占比分别为16.25%、15.00%、15.00%、12.50%;预后不良组患有咽异物感、鼻塞、气喘、上气道梗阻、咽腔狭窄、腭咽关闭不全、SaO2≤40mmHg、AHI≥40次/h、MSaO2≤70%患者占比显著多于预后良好组,差异有统计学意义(P<0.05);多因素Logistic回归分析证实,患有咽异物感、鼻塞、气喘、上气道梗阻、咽腔狭窄、腭咽关闭不全、SaO2≤40mmHg、AHI≥40次/h、MSaO2≤70%为LPRD合并OSAHS患者预后不良的危险因素,均P<0.05。结论:LPRD合并OSAHS患者预后受众多因素的影响,临床在诊疗此类患者应当对上述因素予以相应的关注。

Objective:To investigate the factors influencing the symptoms and prognosis of patients with laryngopharyngeal reflux disease(LPRD)complicated with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods:The clinical data of 80 patients with LPRD combined with OSAHS were retrospectively analyzed.According to whether the patients still had laryngopharyngeal reflux during sleep after discharge,they were divided into a group with good prognosis and a group with poor prognosis.The basic data and information of the two groups after admission were collected.The symptoms and symptoms of LPRD patients with OSAHS were analyzed,and the basic information of the group with good prognosis and the group with poor prognosis were compared.The difference information between the two groups was included in the Logistic model,and quantitative values were performed to identify the risk factors for poor prognosis of LPRD patients with OSAHS.Results:After analysis,the clinical symptoms of LPRD patients with OSAHS are mostly pharyngeal foreign body sensation,allergic rhinitis,asthma,and upper airway obstruction,accounting for 16.25%,15.00%,15.00%,12.50%,respectively.The poor prognosis group suffered from pharyngeal foreign body sensation,allergic rhinitis,asthma,upper airway obstruction,pharyngeal stenosis,velopharyngeal insufficiency,SaO2≤40mmHg,AHI The proportion of patients with≥40 times/h and MSaO2≤70%was significantly higher than that of the good prognosis group,and the difference was statistically significant,P<0.05.Multivariate logistic regression analysis confirmed that patients with pharyngeal foreign body sensation,allergic rhinitis,asthma,upper airway obstruction,pharyngeal cavity stenosis,velopharyngeal insufficiency,SaO2≤40mmHg,AHI≥40 times/h,MSaO2≤70%are LPRD The risk factors for poor prognosis of patients with OSAHS were all P<0.05.Conclusion:The prognosis of PATIENTS with LPRD combined with OSAHS is affected by many factors,and the above factors should be paid corresponding attention to in clinical diagnosis and treatment of such patients.