曲美他嗪联合地尔硫卓治疗心绞痛的疗效研究

Study on effect of trimetazidine combined with diltiazem on angina pectoris

目的研究曲美他嗪联合地尔硫卓治疗心绞痛的效果。方法 80例心绞痛患者,随机分为观察组与对照组,每组40例。两组患者均接受常规治疗,对照组采取曲美他嗪治疗,观察组采取曲美他嗪联合地尔硫卓治疗。比较两组治疗效果,心绞痛发作次数、发作时间,不良反应发生情况。结果观察组的总有效率95.00%高于对照组的77.50%,差异具有统计学意义(P<0.05)。观察组心绞痛发作次数显著少于对照组,心绞痛发作时间短于对照组,差异具有统计学意义(P<0.05)。观察组的不良反应发生率5.00%显著低于对照组的25.00%,差异具有统计学意义(P<0.05)。结论对于心绞痛患者运用曲美他嗪联合地尔硫卓治疗,可以有效控制病情,疗效显著,安全可靠。

Objective To study the effect of trimetazidine combined with diltiazem on angina pectoris.Methods A total of 80 patients with angina pectoris were randomly divided into observation group and control group,with 40 cases in each group.Both groups received conventional therapy.The control group was treated with trimetazidine,and the observation group was treated with trimetazidine combined with diltiazem.The therapeutic effect,attacks of angina pectoris,the duration of the attacks,and the occurrence of adverse reactions were compared between the two groups. Results The total effective rate 95.00% of the observation group was obviouslyhigher than 77.50% of the control group, and the difference was statistically significant (P<0.05). The attacks ofangina pectoris of the observation group was significantly less than that of the control group, and the duration of theattacks was significantly shorter than that of the control group. The difference was statistically significant (P<0.05).The incidence of adverse reactions 5.00% of the observation group was significantly lower than 25.00% of thecontrol group, and the difference was statistically significant (P<0.05). Conclusion Trimetazidine combined withdiltiazem shows remarkable efficacy on angina pectoris patients, and it can effectively control the conditions ofpatients.