非小细胞肺癌恶性胸腔积液的局部辨证分型分布及生存期差异研究

Study on the distribution of Chinese medicine syndrome types by local differentiation and their differences of the survival time in NSCLC with malignant pleural effusion

目的:分析非小细胞肺癌合并恶性胸腔积液患者证型分布及生存期差异,为应用局部辨证法指导非小细胞肺癌合并恶性胸腔积液的治疗提供理论基础。方法:通过回顾性研究2015年1月1日至2018年3月31日就诊于北京中医药大学东方医院肿瘤科住院病房的非小细胞肺癌合并恶性胸腔积液102例患者进行局部辨证分型,记录患者性别、年龄、发病部位以及生存期,比较湿热毒证、寒湿毒症两种证型间患者各项资料的差异。结果:非小细胞肺癌合并恶性胸腔积液患者中寒湿毒证(70.6%,72/102)患者多于湿热毒证(29.4%,30/102),两种证型患者性别、年龄、发病部位无显著性差异,寒湿毒证平均生存期为9.46个月、湿热毒证为5.21个月,差异有统计学意义(P<0.05)。结论:寒湿毒证是恶性胸腔积液常见证型,且生存期长于湿热毒型。

Objective:To analyze the difference between Chinese medicine syndromes and the survival time in patients with non-small cell lung cancer complicated with malignant pleural effusion,and to provide a theoretical basis for differentiation of local syndromes in the treatment of malignant pleural effusion and improve the clinical efficacy.Methods:A retrospective study including 102 patients from January 1,2015 to March 31,2018 in Dongfang Hospital,Beijing University of Chinese Medicine oncology department ward was designed to identify the differences of distribution of the Chinese medicine syndrome and the gender,age,location and survival time of NSCLC with MPE.Results:Among patients with NSCLC and malignant pleural effusion,cold and damp toxin syndrome(70.6%,72/102)is more than damp and heat toxin syndrome(29.4%,30/102).There is no difference in gender,age,location between the two syndrome types of patients.The survival time of patients with the two syndromes was:cold and damp toxin syndrome(9.46 months),damp and heat toxin syndrome(5.21 months),and the difference in survival time was statistically significant(P<0.05).Conclusion:In NSCLC with MPE,the cold-dampness toxicity is more common,and the survival time is longer than the damp-heat toxicity type.