摘要
The first copper-catalyzed enantioselective arylcyanation of styrenes has been developed using readily available anilines as aryl radical precursors under mild conditions,which enables easy access to chiral 2,3-diaryl propionitriles with moderate to good enantiose-lectivities.This operationally straightforward reaction exhibits broad substrate scope and functional group tolerance.Notably,this method has been applied to the synthesis of chiral AlEgen as well as estrogen receptor-B agonist(R)-diarylpropionitrile(DPN).
基金
We are grateful for financial support from the National Nature Science Foundation of China(Nos.21532009,91956202,21821002 and 21790330)
the Science and Technology Commission of Shanghai Municipality(Nos.20JC1417000,19590750400 and 17JC1401200)
the strategic Priority Research Program(No.XDB20000000)
the Key Research Program of Frontier Science(QYZDJSSWSLH055)
the International Partnership Program(No.121731KY5B20190016)of the Chinese Academy of Sciences.
