摘要
A new dual plldium/scandium catalysis starting fromβ-alkynyl ketones and o alkynyl anilines is reported for the first time,leading to the atom-economic synthesis of rotationally hindered C3-naphthylated indoles in moderate to good yields and high regioselectivi-ty.This method can tolerate normal air conditions,and features the use of palladium/scandium cooperative catalysts without any ligand,facile double annulation involving various internal alkynes,and good functional group tolerance.
基金
We are grateful for financial support from the National Natural Science Foundation of China(Nos.21871112 and 21971090).