Dual Palladium/Scandium Catalysis toward Rotationally Hindered C3-Naphthylated Indoles from β-Alkynyl Ketones and o-Alkynyl Anilines

A new dual plldium/scandium catalysis starting fromβ-alkynyl ketones and o alkynyl anilines is reported for the first time,leading to the atom-economic synthesis of rotationally hindered C3-naphthylated indoles in moderate to good yields and high regioselectivi-ty.This method can tolerate normal air conditions,and features the use of palladium/scandium cooperative catalysts without any ligand,facile double annulation involving various internal alkynes,and good functional group tolerance.