布地奈德联合不同药物雾化吸入治疗儿童哮喘急性发作的疗效比较

目的分析布地奈德联合不同药物雾化吸入治疗儿童哮喘急性发作的临床效果。方法选取2015年4月至2020年4月磐安县人民医院收治的哮喘急性发作患儿100例,以双盲随机抽样法分为观察组和对照组,每组各50例。对照组采纳布地奈德+异丙托溴铵雾化吸入,观察组采纳布地奈德+异丙托涣铵+特布他林雾化吸入,连续治疗7 d,比较分析两组的临床疗效和血清炎性因子水平变化。结果观察组临床总有效率(96.00%)明显高于对照组(74.00%),治疗7 d后,观察组血清TNF-α、IL-8、IL-6因子水平均低于对照组,差异均有统计学意义(P<0.05)。结论布地奈德+异丙托溴铵+特布他林雾化吸入可有效缓解哮喘急性发作患儿临床症状,减轻炎症反应,值得临床借鉴。

Objective To analyze the clinical effect of budesomde combined with different drugs inhalation inhalation in the treatment of acute asthma attacks in children.Methods A total of 100 children with acute asthma attack admitted to Pan'an County People's Hospital from April 2015 to April 2020 were selected and divided into observation group and control group by double-blind random sampling method,with 50 cases in each group.The control group adopted budesonide+ipratropium bromide nebulized inhalation,and the observation group adopted budesonide+ipratropium bromide nebulized inhalation for 7 days of continuous treatment.The clinical efficacy and efficacy of the two groups were compared and analyzed.Changes in serum inflammatory factor levels.Results The total clinical effective rate(96.00%)of the observation group was significantly higher than that of the control group(74.00%).After 7 days of treatment,the serum TNF-α,IL-8,and IL-6 levels of the observation group were lower than those of the control group,and there were differences statistically significant(P<0.05).Conclusion Aerosol inhalation of budesonide+ipratropium bromide+terbutaline can effectively alleviate the clinical symptoms and reduce inflammation in children with acute asthma attacks,which is worthy of clinical reference.