肠道菌群与骨质疏松症的发病机制

Pathogenesis of osteoporosis and gut microbiome

肠道菌群是指存在于肠道内的微生物群落,数目超过1014,基因数约为人类的150倍,其对人体健康起着至关重要的作用。近年来研究发现肠道菌群与骨质疏松症关系密切,肠道菌群可通过免疫机制、内分泌、脑肠轴以及代谢产物影响机体骨代谢,肠道菌群为骨质疏松症的防治提供了新思路、新靶点。

Gut microbiome(GM)is the microbial community colonizing in the intestinal tract,the number exceeds 1014,and the number of genes is about 150 times that of human beings.GM plays vital roles in human health.In recent years,many researches have found that GM is closely related to osteoporosis.GM can affect bone metaboism through immune mechanism,endocrine,brain-gut-axis,and metabolites,providing new ideas and new targets for the prevention and treatment of osteoporosis.