血清Hcy Hs-CRP TNF-αIL-6水平与急性缺血性脑梗死严重程度的关系研究

Relationship Between Serum Levels of Hcy Hs-CRP TNF-αIL-6 and the Severity of Acute Ischemic Cerebral Infarction

目的:对急性缺血性脑梗死病情的严重程度与高敏C反应蛋白(hs-CRP)以及肿瘤坏死因子-α(TNF-α)和血清同型半胱氨酸(Hcy)、白介素6(IL-6)之间存在的关系进行探究。方法:选择2015年1月至2018年12月在我院接受治疗的急性缺血性脑梗死的患者,共包括260例。另选我院门诊体检健康人群120例作为对照组。根据病情严重程度分为轻度卒中(115例),中度卒中(85例),重度卒中(60例);根据脑梗死面积分为小面积梗死(122例),中等面积梗死(83例),大面积梗死(55例);对血清中各个炎性因子的水平进行检验,方法采用酶联免疫吸附法(ELISA),采用Pearson相关性分析法分析上述因子水平与NIHSS得分的关系。统计分析所有患者的病情严重程度和脑梗死面积与血清Hcy、hs-CRP、IL-6和TNF-α水平情况。结果:观察组Hcy、Hs-CRP、TNF-α、IL-6比较均明显高于对照组(P<0.05)。轻度梗死组患者Hs-CRP、Hcy、TNF-α、IL-6水平的明显低于中度组和重度组,且中度组患者明显低于重度组(P<0.05)。小面积梗死组患者Hs-CRP、Hcy、TNF-α、IL-6水平的明显低于中等面积梗死组和大面积梗死组,且中等面积梗死组患者Hs-CRP、Hcy、TNF-α、IL-6水平明显低于大面积梗死组(P<0.05)。将Hs-CRP、Hcy、TNF-α、IL-6作为自变量,将NIHSS评分作为因变量,经过Pearson相关分析显示,Hs-CRP、Hcy、TNF-α、IL-6和NIHSS评分均呈正相关(P<0.05)。结论:血清Hcy、hs-CRP、IL-6和TNF-α水平与急性缺血性脑梗死之间存在明显的正相关关系,能够运用这些指标来对患者病情进行相应的评估。

Objective:To investigate the severity of acute ischemic cerebral infarction with high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),serum homocysteine(Hcy)and interleukin-6(IL-6),and to explore the relationship between them.Methods:Patients who underwent acute ischemic cerebral infarction in our hospital from January 2015 to December 2018 were enrolled.Another 120 healthy people in our outpatient clinic were selected as the control group.According to the severity of the disease,they were divided into mild stroke(115 cases),moderate stroke(85 cases),and severe stroke(60 cases).According to the area of cerebral infarction,they were divided into small area infarction(122 cases)and medium area infarction(83 cases)and large area infarction(55 cases);the level of each inflammatory factor in serum was tested by enzyme-linked immunosorbent assay(ELISA),and the relationship between the above factors and NIHSS score was analyzed by Pearson correlation analysis.The severity of the disease and the area of cerebral infarction and serum Hcy,hs-CRP,IL-6 and TNF-αlevels were statistically analyzed.Results:The levels of Hcy,Hs-CRP,TNF-αand IL-6 in the observation group were significantly higher than those in the control group(P<0.05).The levels of Hs-CRP,Hcy,TNF-α,and IL-6 in the mild infarction group were significantly lower than those in the moderate and severe groups,and the patients in the moderate group were significantly lower than the recombination(P<0.05).The levels of Hs-CRP,Hcy,TNF-α,and IL-6 in patients with small infarction were significantly lower than those in moderate infarction group and large infarction group,and those in moderate infarction group were significantly lower than those in large infarction group(P<0.05).Hs-CRP,Hcy,TNF-α,and IL-6 were used as independent variables,and NIHSS score was used as the dependent variable.Pearson correlation analysis showed that Hs-CRP,Hcy,TNF-α,IL-6 and NIHSS scores were positively correlated(P<0.05).Conclusion:There is a significant positive correlation between serum levels of Hcy,hs-CRP,IL-6 and TNF-αand acute ischemic cerebral infarction.These indicators can be used to assess the patient's condition.