早发型新生儿败血症NLR ELR和PLR指标变化及临床意义

Changes and Clinical Significance of NLR,ELR and PLR in Early-onset Neonatal Sepsis

目的:探讨早发型新生儿败血症患儿中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)、嗜酸性粒细胞/淋巴细胞比值(ELR)的变化及临床意义。方法:将2017年4月至2020年5月在我院住院并确诊为早发型败血症的新生儿58例为败血症组,患儿年龄为0~72h,同期住院的非感染的新生儿40例为对照组。比较两组资料的外周血NLR、ELR及PLR水平,评价早发型新生儿败血症NLR、ELR和PLR指标变化及临床意义。结果:败血症组和对照组结果比较,败血症组指标NLR、ELR水平明显高于对照组,差异有统计学意义(P<0.05)。ROC曲线分析,曲线下面积NLR>ELR>PLR,NLR截断值为1.987,灵敏度为78.87%,特异度为88.11%,曲线下面积为0.752,ELR截断值为0.117,灵敏度为70.81%,特异度为77.25%,曲线下面积为0.689。结论:NLR的诊断效能高于ELR,可以辅助诊断早发型新生儿败血症,对患儿疾病的诊断及评估有一定的参考价值。

Objective:To observe the clinical significance and the changes on the neutrophil-to-lymphocyte,the eosinophil-to-lymphocyte,the platelet-to-lymphocyte with Neonatal septicemia.Methods:From April 2017 to May 2020,58 newborns with early-onset sepsis in our hospital were selected as sepsis group,and 40 non infected newborns in the same period were selected as control group.The levels of NLR,ELR and PLR were compared between the two groups.The changes and clinical significance of NLR,ELR and PLR in early-onset neonatal sepsis were evaluated.Results:The levels of NLR and ELR in sepsis group were significantly higher than those in control group(P<0.05).ROC curve analysis showed that area under the curve NLR>ELR>PLR,NLR cutoff value was 1.987,sensitivity was 78.87%,specificity was 88.11%,area under the curve was 0.752,ELR cutoff value was 0.117,sensitivity was 70.81%,specificity was 77.25%,area under the curve was 0.689.Conclusion:The diagnostic efficiency of NLR is higher than that of ELR,which can assist in the diagnosis of early-onset neonatal sepsis,and has a certain reference value for the diagnosis and evaluation of children's diseases.