CA125 CA199 HE4及ROMA指数对卵巢癌预后预测价值

The Predictive Value of CA125 CA199 HE4 and ROMA Index on the Prognosis of Ovarian Cancer

目的:探讨糖类抗原125(Carbohydrate Antigen 125,CA125)、糖类抗原199(Carbohydrate Antigen199,CA199)、人附睾蛋白4(Human Epididymisprotein4,HE4)和卵巢癌风险评估模型(Risk Of Ovarian Malignancy Algorith,ROMA)指数对卵巢癌预后的预测价值。方法:回顾性分析2017年3月至2019年3月在本院收治的70例卵巢癌患者资料,根据患者生存情况,将39例存活患者列为生存组,31例死亡患者列为死亡组。记录两组患者的CA125、CA199、HE4和ROMA指数,并Logistic回归分析上述指标对于卵巢癌预后的影响,ROC曲线分析上述指标对疾病预后的预测价值。结果:死亡组的CA125、CA199、HE4和ROMA指数均明显高于生存组,组间差异有统计学差异(P<0.05)。多因素Logistic回归分析显示,CA125、CA199、HE4和ROMA指数为卵巢癌预后的独立影响因素(P<0.05)。ROC曲线分析显示,CA125、CA199、HE4、ROMA指数和四项联合对卵巢癌预后的曲线下面积(Area Under Curve,AUC)分别为0.758、0.874、0.800、0.833和0.887,CA199和四项联合对预后的预测价值较好。结论:CA125、CA199、HE4和ROMA指数均为卵巢癌预后的独立危险因素,且上述指标的水平高低均可预测疾病预后,并以四项联合的预测价值最佳,临床可辅助通过四项联合检测预测患者预后。

Objective:To investigate carbohydrate antigen 125(CA125),carbohydrate antigen 199(CA199),human epididymisprotein 4(HE4)and risk of ovarian malignancy algorith(ROMA)index for the prognosis of ovarian cancer.Methods:A retrospective analysis of 70 cases of ovarian cancer treated in our hospital from March 2017 to March 2019 was conducted,depending on the patient's survival,39 surviving patients were classified as the survival group,31 patients who died were classified as death group.The CA125,CA199,HE4 and ROMA indexes of the two groups of patients was recorded,and logistic regression analysis was applied to the impact of the above indexes on the prognosis of ovarian cancer,ROC curve analysis was applied to the predictive value of the above indexes on the prognosis of the disease.Results:The CA125,CA199,HE4 and ROMA indexes of the death group were significantly higher than those of the survival group,and there were statistical differences between the groups(P<0.05).Multivariate logistic regression analysis showed that CA125,CA199,HE4 and ROMA index were independent factors influencing the prognosis of ovarian cancer(P<0.05).ROC curve analysis showed that the area under the curve(Area Under Curve,AUC)of the CA125、CA199、HE4、ROMA index and four combinations for the prognosis of ovarian cancer was 0.758,0.874,0.800,0.833 and 0.887,respectively.The CA199 and four combinations had better predictive value for prognosis.Conclusion:CA125、CA199、HE4 and ROMA indices are independent prognostic risk factors for ovarian cancer.The level of the above indexes can predict the prognosis of the disease,the prediction value of the four combinations is the best,and the clinical can be used to predict the prognosis of the patients through the four combined tests.