干眼相关角膜上皮损伤的修复

Repair of dry eye-related corneal epithelial damage

角膜上皮损伤是指由各种原因导致的角膜上皮功能与完整性被破坏,导致角膜上皮细胞层部分或全层缺失。干眼是角膜上皮损伤的常见原因,也是角膜上皮损伤后延迟愈合或不愈合的主要原因。我国研究者强调泪膜稳定性的改变是干眼发病的核心机制,这也提示我们改善泪膜稳定性在干眼及其相关角膜上皮损伤修复中的重要性。目前临床上应用眼表润滑剂补充泪液中水液、黏蛋白、脂质等成分,同时应用抗炎药物以提高泪膜稳定性。当眼表微环境存在异常或损伤时,其角膜上皮损伤位点积聚的生长因子满足不了损伤快速修复的需要,需要及时局部补充外源性生长因子,促进损伤愈合。本文从眼表润滑剂、抗炎治疗、促进角膜上皮修复几个方面就干眼相关角膜上皮损伤的修复进行综述。

Corneal epithelial injury refers to the destruction of corneal epithelial function and structural integrity caused by various reasons.Dry eye is a common cause of corneal epithelial damage and it also delays the healing of corneal epithelial wound.The change of tear film stability is a main mechanism of dry eye disease,which implies an important role of improving the tear film stability in dry eye and the repair of dry eye-related corneal epithelial damage.Ocular surface lubricants can be used to supplement the water-like liquid,mucin and lipid that tears naturally have.Anti-inflammatory drugs can improve the stability of tear film.When the ocular surface microenvironment is affected,the growth factors of the tear are unable to meet the needs of rapid repair of the damage.Therefore,it is necessary to supplement exogenous growth factor to promote injury healing of corneal epithelium.In this article,the repair of corneal epithelial damage associated with dry eye were reviewed,including the therapies of ocular surface lubricant,anti-inflammation and promoting repair of corneal epithelium.