红细胞分布宽度与原发性高血压患者血压变异性的相关性分析

Correlation analysis of red blood distribution width levels with blood pressure variability in patients with prim-ary hypertension

目的分析红细胞分布宽度(RDW)在原发性高血压患者与血压变异性(BPV)的相关性。方法回顾性分析2017年10月~2019年6月北京市西城区平安医院收治的220例原发性高血压患者的临床资料。监测所有受试者24 h动态血压,测定血清RDW和血脂等生化指标。根据RDW四分位值将患者分为4组:Ⅰ组58例(RDW<12.40%)、Ⅱ组56例(12.40%≤RDW<12.90%)、Ⅲ组52例(12.90%≤RDW<13.50%)、Ⅳ组54例(RDW≥13.50%)。本研究以24 h动态血压读数的标准差作为BPV指标[包括24 h收缩压标准差(24 h SSD)、24 h舒张压标准差(24 h DSD)],比较不同RDW水平患者的BPV情况,分析RDW与BPV的相关性。结果BPV指标比较结果显示,24 h SSD、24 h DSD在Ⅳ组高于Ⅲ组、Ⅲ组高于Ⅱ组、Ⅱ组高于Ⅰ组,差异有统计学意义(P<0.05)。Pearson相关性分析结果显示,RDW与24 h SSD、24 h DSD呈正相关(r=0.727、0.557,P<0.05)。结论原发性高血压患者RDW水平与BPV呈正相关,RDW与原发性高血压患者BPV密切相关。

Objective To analyze the correlation of red blood distribution width(RDW)levels with blood pressure variability(BPV)in patients with primary hypertension.Methods Retrospective analysis was made on the clinical data of 220 patients with essential in Beijing Xicheng District Pingan Hospital from October 2017 to June 2019.24 hours ambulatory blood pressure monitoring was conducted.Plasma levels of RDW,fasting blood glucose and lipids were also examined.Patients were divided into 4 groups based on their RDW levels:groupⅠwith 58 cases(RDW<12.4%),groupⅡwith 56 cases(12.4%≤RDW<12.9%),groupⅢwith 52 cases(12.9%≤RDW<13.5%),groupⅣwith 54 cases(RDW≥13.5%).In this study,the standard deviation of 2-hour ambulatory blood pressure reading was used as the index of BPV,including 24 hours systolic blood pressure standard deviation(24 h SSD),24 hours diastolic blood pressure standard deviation(24 h DSD).The BPV of patients with different RDW levels was compared and the correlation between RDW and BPV was analyzed.Results Comparison of BPV indicators showed that the levels of 24 h SSD and 24 h DSD of groupⅣwere higher than those of the groupⅢ,the levels of 24 h SSD and 24 h DSD of groupⅢwere higher than those of the groupⅡ,and the levels of 24 h SSD and 24 h DSD of groupⅡwere higher than those of the groupⅠ,and the differences were statistically significant(P<0.05).The result of Pearson correlation analysis showed that RDW was positively correlated with 24 hours SSD and 24 hours DSD(r=0.727 and 0.557,P<0.05).Conclusion The RDW level of patients with essential hypertension is positively correlated with BPV,RDW is closely related to BPV in patients with essential hypertension.