奥氮平在预防晚期非小细胞肺癌患者化疗所致恶心、呕吐中的临床应用

Clinical application of Olanzapine in preventing nausea and vomiting caused by chemotherapy in patients with advanced non-small cell lung cancer

目的探讨奥氮平预防晚期非小细胞肺癌患者化疗所致恶心、呕吐的临床效果及安全性。方法选取2016年11月~2019年11月就诊于大连市友谊医院的50例晚期非小细胞肺癌化疗所致恶心、呕吐患者,按照随机数字表法将其分为观察组(n=25)及对照组(n=25)。两组均给予顺铂联合紫杉醇/多西他赛化疗。对照组患者预防性应用盐酸昂丹司琼注射液,观察组患者预防性应用奥氮平联合盐酸昂丹司琼注射液止吐。记录两组患者化疗后恶心、呕吐症状完全缓解率,比较两组的生活质量及不良反应发生情况。结果两组患者的急性恶心、急性呕吐完全缓解率比较,差异无统计学意义(P>0.05)。观察组患者的延迟性恶心、延迟性呕吐完全缓解率均高于对照组,差异有统计学意义(P<0.05)。观察组患者生活质量量表的情绪功能评分高于对照组,差异有统计学意义(P<0.05);观察组患者生活质量量表的恶心与呕吐、食欲下降评分低于对照组,差异有统计学意义(P<0.05)。观察组患者的嗜睡和头晕发生率高于对照组,差异有统计学意义(P<0.05)。结论奥氮平在预防晚期非小细胞肺癌患者化疗所致的延迟性恶心、呕吐中有较好的疗效,且可提高患者的生活质量。

Objective To investigate the clinical effect and safety of Olanzapine in preventing nausea and vomiting caused by chemotherapy in patients with advanced non-small cell lung cancer.Methods A total of 50 patients with advanced non-small cell lung cancer chemotherapy-induced nausea and vomiting in Dalian Friendship Hospital from November 2016 to November 2019 were selected,and they were divided into the observation group(n=25)and the control group(n=25)by the random number table method.Both groups were given Cisplatin combined with Paclitaxel/Docetaxel chemotherapy.Patients in the control group were treated with Ondansetron Hydrochloride Injection preventively,and in the observation group,they were treated with Olanzapine combined with Ondansetron Hydrochloride Injection to stop vomiting.The complete remission rate of nausea and vomiting after chemotherapy was recorded.The quality of life and incidence of adverse reactions between the two groups were compared.Results There was no significant difference in the complete remission rate of acute nausea and acute vomiting between the two groups(P>0.05).The complete remission rates of delayed nausea and delayed vomiting in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The emotional function score on the quality of life scale of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The nausea,vomiting and decreased appetite scores on the quality of life scale of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).The incidence of drowsiness and dizziness in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Olanzapine has a good effect on preventing delayed nausea and vomiting caused by chemotherapy in patients with advanced non-small cell lung cancer,and it can improve the quality of life of patients.