梅毒感染孕产妇所产新生儿随访结果分析

Analysis of follow-up results of newborns of maternal with syphilis infection

目的分析梅毒感染孕产妇所产新生儿的随访结果。方法回顾性分析2013年1月—2019年12月龙川县妇幼保健院接收的68例梅毒感染孕产妇所产新生儿(68例)的临床资料,跟踪随访其治疗效果。结果68例产妇均为产前检查发现TPPA阳性或者RPR滴度异常者,母体血清RPR 1:1有6例;RPR 1:2~1:4有44例;RPR>1:4有18例。68例疑似梅毒新生儿RPR滴度从阴性至1:8不等,其中有37例新生儿RPR阴性未进行治疗,定期进行观察;RPR 1:1有15例;RPR 1:2~1:8有10例,均接受相应治疗。31例经治疗后具有一定程度好转,与治疗前比,治疗后,RPR 1:1有11例转阴;RPR 1:2~1:8有5例转阴,5例滴度下降;TPPA>1:8中有1例转阴,4例滴度下降。结论给予孕产妇提供早期综合防治措施,提高妊娠梅毒早期诊断及规范治疗,是预防新生儿梅毒的重要举措,可在一定程度上降低新生儿感染率。

Objective To investigate and analyze the follow-up results of newborns of maternal with syphilis infection.Methods A retrospective analysis was used to collect the clinical data of 68 newborns(68 cases)of maternal with syphilis infection admitted to our hospital from January 2013 to December 2019,the therapeutic effect was followed up and the results were analyzed.Results 68 cases of maternal were found to be TPPA positive or RPR titer abnormal by prenatal examination.There were 6 cases of maternal with serum RPR1:1,44 cases with RPR1:2~1:4 and 18 cases with RPR>1:4.The RPR titer of 68 suspected syphilis newborns ranged from negative to 1:8,among them,37 cases were RPR negative and and did not receive treatment,with regular observation;15 cases were RPR 1:1 and 10 cases were RPR 1:2~1:8,all received targeted treatment.31 cases had some degree of improvement after treatment,compared with before treatment,11 cases of RPR1:1 turned negative after treatment;in RPR 1:2~1:8,5 cases turned negative and 5 cases of titers were decreased;in TPPA>1:8,1 case turned negative and 4 cases of titers were decreased.Conclusion It is an important measure to prevent neonatal syphilis to provide early chain seamless comprehensive prevention and control measures for maternal and improve the early diagnosis and standardized treatment of syphilis in pregnancy,which can reduce the infection rate of newborn to a certain extent.