幽门螺杆菌抗体分型在袁州区居民胃十二指肠疾病临床应用的相关研究

Study on the clinical application of Helicobacter pylori antibody typing in gastroduodenal diseases of residents in Yuanzhou district

目的分析幽门螺杆菌(Hp)抗体分型与袁州区居民胃十二指肠疾病的关系。方法回顾性分析2019年6月—2020年6月因上腹不适阳性征于宜春市第二人民医院消化内科就诊的袁州区患者的临床资料,将接受胃镜检查与14C尿素呼气试验检查阳性的胃十二指肠疾病患者200例纳入观察组,将同期200例健康体检者纳入对照组,均进行Hp抗体检测。比较2组HpⅠ型、HpⅡ型、HpⅠ+Ⅱ型抗体阳性率及与胃十二指肠疾病的关系。结果观察组HpⅠ型抗体阳性率高于对照组,HpⅡ型抗体阳性率低于对照组,差异有统计学意义(P<0.05);2组HpⅠ+Ⅱ型抗体阳性率比较,差异无统计学意义(P>0.05)。在胃溃疡、胃癌中HpⅠ型抗体阳性率较高,单纯慢性胃炎中HpⅡ型抗体阳性率较高。结论通过检测Hp抗体分型,可评估胃十二指肠疾病病情程度、预后情况,且可及时规范根除Hp感染,减少耐药发生。

Objective To analyze the relationship between helicobacter pylori(Hp)antibody typing and gastroduodenal disease in Yuanzhou district.Methods a retrospective analysis in June 2019 to June 2020 from epigastric discomfort positive sign on our digestive internal medicine clinic patients clinical data,will accept gastroscopy with 14 c-urea breath test positive for 200 cases of patients with gastroduodenal diseases into the observation group,the clinical data of 200 cases of healthy check-up will be the same period included in the control group,both for Hp antibody detection.Compare two groups of HpⅠ,HpⅡ,HpⅠ+Ⅱantibody positive rate and the relationship with gastroduodenal diseases.Results observation group Hp typeⅠantibody positive rate is higher than the control group,Hp typeⅡantibody positive rate is lower than the control group,the difference was statistically significant(P<0.05);Two groups of HpⅠ+Ⅱrate of positive of antibody of type comparison,there was no statistically significant difference(P>0.05).HpⅠtype in gastric ulcer,gastric cancer antibody positive rate is higher,simple type chronic gastritis in HpⅡantibody positive rate is higher.Conclusion The detection of Hp antibody typing in gastroduodenal diseases of residents in Yuanzhou District can assess the severity and prognosis of gastroduodenal diseases of residents,and can promptly eradicate Hp infection and reduce the occurrence of drug resistance.