阿托伐他汀联合氯吡格雷对AMI患者临床疗效及预后的影响研究

Effects of Atorvastatin combined with Clopidogrel on the clinical efficacy and prognosis of AMI patients

目的探讨阿托伐他汀联合氯吡格雷对急性心肌梗死(AMI)患者临床疗效及预后的影响。方法选取2015年8月—2019年11月雷州市人民医院收治的84例急性心肌梗死患者为研究对象,按随机数字表法分为2组各42例。对照组接受常规方案治疗,观察组则采用阿托伐他汀联合氯吡格雷方案治疗,对比2组疗效及患者预后情况。结果观察组治疗后LVEF水平高于对照组,LVESd和LVEDd水平低于对照组(P<0.05);观察组治疗总有效率高于对照组(P<0.05);观察组心血管事件发生率及随访病死率均低于对照组(P<0.05)。结论在AMI治疗中应用阿托伐他汀联合氯吡格雷可以更有效地改善患者心功能,降低心血管事件和病死率,值得临床借鉴。

Objective To investigate the effect of atorvastatin combined with clopidogrel on the clinical efficacy and prognosis of patients with acute myocardial infarction(AMI).Methods A total of 84 patients with acute myocardial infarction admitted to our hospital from August 2015 to November 2019 were selected as the research objects and grouped according to the random table method of Numbers,with 42 patients in each group.The control group received conventional regimen,while the observation group received atorvastatin combined with clopidogrel regimen.The efficacy and prognosis of the two groups were compared.Results After treatment,LVEF level in the two groups was higher than that before treatment,while LVESD and LVEDD levels were lower than that before treatment(P<0.05).LVEF level in the observation group was higher than that in the control group,and LVESD and LVEDD levels were lower than that in the control group(P<0.05).The total effective rate of the observation group was higher than that of the control group(P<0.05).The incidence of cardiovascular events and follow-up mortality in the observation group were lower than those in the control group(P<0.05).Conclusion Atorvastatin combined with clopidogrel in the treatment of AMI can improve cardiac function,reduce cardiovascular events and mortality,and is safe and worthy of application.